Can the microbiome predict Parkinson’s?
08 February, 2021
- A report finds that Parkinson’s disease is connected with alterations in the composition of the gut microbiome.
- In Parkinson’s disease, the gut bacteria’s capability to breakdown fat is altered, which makes it harder to modify bile acid production.
- Disruptions in bile acid production is actually a probable indicator of the problem.
- Treatment options targeting the microbiome and bile acids can help delay the progression of Parkinson’s disease.
- The gut microbiome influences many systems of your body.
It could create neurochemicals, such as serotonin, and communicate with the central nervous program. Its marriage with the brain may effect dementia and autism.
In a fresh study, researchers investigated the link between gut bacteria and Parkinson’s disease.
“It’s becoming more and more clear that gut well being has tight links with brain health and wellbeing,” says Dr. Peipei Li, a former postdoctoral fellow at Van Andel Institute and the study’s lead author.
“Our results provide exciting new possibilities for better understanding this romance and perhaps for developing new ways to diagnose - and even handle - Parkinson’s.”
The researchers published their results recently in the journal Metabolites.
Microbiome changes on the appendix
The team collected tissue samples of the appendix, ileum, and liver - all of which are likely involved in producing bile acids - from persons with Parkinson’s disease and a control group of men and women without the condition.
Bile is a fluid manufactured found in the liver and placed found in the gallbladder. After someone eats, the material is released to their intestines to support break down fats.
Bile salts are among the key parts in bile that make it break down fats.
To study differences on microbial composition, the researchers compared the appendix microbiome of 12 people with Parkinson’s disease with 16 from the control group.
They found the appendixes of those with the condition had higher degrees of Peptostreptococcaceae, Lachnospiraceae, and Burkholderiales.
“Burkholderia has also been reported to infect the brain. Of particular interest, Burkholderia species encode the rate-limiting enzyme for secondary bile acid synthesis, highlighting the actual fact that the appendix microbiome of [persons with Parkinson’s disease] has an enrichment of microbiota that metabolize bile acids,” wrote the authors.
Furthermore, the appendixes of folks with Parkinson’s disease showed decreased:
- Methanobacteriales
- Odoribacter
- Clostridium
- unclassified Sutterellaceae
- Escherichia
- Dysregulated metabolic pathways
“Bacterial species accountable for the production of secondary bile acids on the large intestine were elevated on the [Parkinson’s disease] appendix,” wrote the authors.
Based on the microbiome alterations, the experts looked to see in the event Parkinson’s disease was connected with changes in microbial metabolic pathways in the appendix. The most important change was an impaired lipid fat burning capacity and a lack of fatty acid metabolism.
For that reason dysregulated lipid fat burning capacity, the team as well tested if the proteins mixed up in metabolic pathways were as well altered found in the appendix and ileum.
In the appendix and ileum of men and women with Parkinson’s disease, there was a reduction in proteins affecting lipid metabolic rate. In addition, there is impairment in the pathways involved with various other cellular activity, namely in protein localization, antigen demonstration, glycolysis, and immune activity.
Source: www.medicalnewstoday.com
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