New chronic fatigue syndrome test is 84 percent accurate
11 July, 2018
Myalgic encephalomyelitis/chronic fatigue syndrome does not currently have a diagnostic test. But this may soon change, as researchers have developed a test that can predict it with an unprecedented level of accuracy.
Currently, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is estimated to affect more than 1 million people in the United States, and up to 24 million people worldwide.
This often debilitating condition is characterized by feelings of extreme exhaustion, muscle and joint pain, and insomnia, as well as difficulty concentrating or remembering things.
The causes of ME/CFS remain unknown, and in the absence of a proper diagnostic test for it, healthcare professionals have to exclude other disorders and examine a patient's history before they can tell whether a person has ME/CFS or not.
However, this may soon change, as a team of researchers led by those at the Center for Infection and Immunity (CII) at Columbia University's Mailman School of Public Health in New York City, NY, have engineered a highly accurate test for the disorder.
The researchers detail their findings in a new study recently published in the journal Scientific Reports. Dr. Dorottya Nagy-Szakal, a CII researcher, is the first author of the paper.
Engineering an ME/CFS diagnostic test
Dr. Nagy-Szakal and team examined the blood samples of 50 people with ME/CFS and compared them with those of 50 age-matched healthy controls.
Using a special technique that identifies molecules by measuring their mass, the scientists found 562 metabolites that the ME/CFS patients had in common.
Metabolites are byproducts of the body's metabolism — that is, its ability to process sugars, fats, and proteins. In the recent research, the scientists excluded metabolites resulting from antidepressants or other drugs.
Laboratory tests carried out by Dr. Nagy-Szakal and team revealed that certain metabolites were altered in a way that suggested that the patients' mitochondria — which are the tiny organelles inside the cell responsible for turning nutrients into energy — were not functioning properly.
The results are coherent with previous studies led by other researchers, as well as with research carried out by Dr. Nagy-Szakal and colleagues last year.
In 2017, the team found a distinct pattern of metabolites in people who had both irritable bowel syndrome (IBS) and ME/CFS.
Other studies have reported that 35–90 percent of those with ME/CFS also have IBS. And in the new study, half of the ME/CFS patients also had IBS.